Good Cosmetic Ingredient

DIBROMOCYANOACETAMIDE

Also known as: DBNPA, Acetamide, 2,2-dibromo-2-cyano-, Acetamide, 2-cyano-2,2-dibromo-, 3-02-00-01641, BRN 1761192 (+7 more)

DIBROMOCYANOACETAMIDE (CAS 10222-01-2) is a cosmetic cosmetic ingredient functioning as Antimicrobial. NOAEL 5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 10222-01-2 →

Auto-generated CPSR Part A draft with source citations

Cross-Vertical Regulatory Divergence

DIBROMOCYANOACETAMIDE is classified GHS Danger (H301, H318, H331, H410, H315, H317, H330, H372) in the chemicals database but is allowed in EU cosmetics.

Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

CAS Number

10222-01-2

View industrial chemical safety profile →

Function

Antimicrobial

Safety Rating

GOOD

Chemistry & Identifiers

Formula

C3H2Br2N2O

241.87 g/mol

PubChem CID

25059

IUPAC Name

2,2-dibromo-2-cyanoacetamide

InChIKey

UUIVKBHZENILKB-UHFFFAOYSA-N

UNII: 7N51QGL6MJ Wikidata: Q5204411

Regulatory Status

EU EU Status permitted

US US Status Not specifically regulated

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for DIBROMOCYANOACETAMIDE across SCCS product categories, with measured dermal absorption where available.

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word

Danger

Pictograms

Acute ToxicityHealth HazardCorrosiveEnvironmental Hazard

Hazard Class and Category

Acute Tox. 2; Acute Tox. 3; STOT RE 1; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1

Hazard Statements

H330 Fatal if inhaled
H301 Toxic if swallowed
H372 (inhalation) (respiratory tract)
H315 Causes skin irritation
H318 Causes serious eye damage
H317 May cause an allergic skin reaction
H400 Very toxic to aquatic life
H410 Very toxic to aquatic life with long lasting effects

Specific Concentration Limits / M-factors

inhalation: ATE = 0.24 mg/L dusts or mists; oral: ATE = 118.0 mg/kg bw; M = 1; M = 1

Inserted via ATP: ATP17

Endocrine Disruptor Evidence (Expanded)

Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.

Confirmed Evidence: High (2021)

Health effects: Yes

Affected pathways: Thyroid/Steroidogenesis

Regulatory framework: BPR

Source list: I

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (2)

Endocrine Disruptors

Potential endocrine disrupting compound

Source: NORMAN Suspect List Exchange

Skin Eye Respiratory Irritation

A severe skin & eye irritant.

Source: Hazardous Substances Data Bank (HSDB)

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Biocide

Regulatory List Membership (1)

FDA Substances Added to Food (EAFUS)

Expert Verdict

Expert safety assessment and concern-level summary for DIBROMOCYANOACETAMIDE.

Regulatory Flags

cosing-sourced eu-permitted preservative needs-enrichment fda_food_additive

Known Synonyms

DBNPA Acetamide, 2,2-dibromo-2-cyano- Acetamide, 2-cyano-2,2-dibromo- 3-02-00-01641 BRN 1761192 Caswell No. 287AA 2,2-Dibromo-2-carbamoylacetonitrile EINECS 233-539-7 EPA Pesticide Chemical Code 101801 NSC 98283 XD-7287l Antimicrobial UNII-7N51QGL6MJ

Chemical Function

Biocide

Regulatory Lists

CEDI food_additive; Substances Added to Food (formerly EAFUS) (2/2019) active_ingredient; Europe; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

ChEMBL ID

CHEMBL1878278

View full pharmaceutical profile →

Frequently Asked Questions

Is DIBROMOCYANOACETAMIDE safe in cosmetics?

DIBROMOCYANOACETAMIDE has a safety rating of "GOOD" in our database. EU status: permitted.

Is DIBROMOCYANOACETAMIDE allowed in the EU?

DIBROMOCYANOACETAMIDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does DIBROMOCYANOACETAMIDE do in cosmetics?

DIBROMOCYANOACETAMIDE functions as: Antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 10222-01-2.

Is DIBROMOCYANOACETAMIDE used outside cosmetics?

DIBROMOCYANOACETAMIDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does DIBROMOCYANOACETAMIDE have different safety status in cosmetics vs industrial chemicals?

DIBROMOCYANOACETAMIDE is classified GHS Danger (H301, H318, H331, H410, H315, H317, H330, H372) in the chemicals database but is allowed in EU cosmetics.

Compliance Tools

Check DIBROMOCYANOACETAMIDE compliance across multiple jurisdictions:

Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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