Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Diallyl Sulphide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 71 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 114 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 114 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 20 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
Expert Verdict
Skin and eye irritant with flammable properties (UN 1993, Hazard Class 3, PG III). Natural garlic component with GRAS status in food. Strong garlic odor limits practical cosmetic use. Less allergenic than the disulfide form.
Regulatory Flags
Frequently Asked Questions
Is Diallyl Sulphide safe in cosmetics?
Skin and eye irritant with flammable properties (UN 1993, Hazard Class 3, PG III). Natural garlic component with GRAS status in food. Strong garlic odor limits practical cosmetic use. Less allergenic than the disulfide form. The EU classifies Diallyl Sulphide as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Diallyl Sulphide allowed in the EU?
Diallyl Sulphide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diallyl Sulphide do in cosmetics?
Diallyl Sulphide functions as: Fragrance ingredient, flavoring agent. It is classified as a cosmetic ingredient in our database. CAS number: 592-88-1.
What is the Margin of Safety for Diallyl Sulphide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diallyl Sulphide?
The NOAEL (No Observed Adverse Effect Level) for Diallyl Sulphide is 500 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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