Diallyldimethyl Ammonium Chloride (DADMAC)
INCI: DIALLYLDIMETHYLAMMONIUM CHLORIDE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Diallyldimethyl Ammonium Chloride (DADMAC). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 200 mg/kg bw/day | oral | dog | oral | REACH |
| NOEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Monomer classified as Skin Irrit. 2 (H315), Eye Irrit. 2A (H319), STOT SE 3 (H335); almost exclusively used in polymerized form (Polyquaternium-6, -7, etc.) with substantially lower irritation potential; residual monomer levels in polymer must be controlled.
Frequently Asked Questions
Is Diallyldimethyl Ammonium Chloride (DADMAC) safe in cosmetics?
Monomer classified as Skin Irrit. 2 (H315), Eye Irrit. 2A (H319), STOT SE 3 (H335); almost exclusively used in polymerized form (Polyquaternium-6, -7, etc.) with substantially lower irritation potential; residual monomer levels in polymer must be controlled. The EU classifies Diallyldimethyl Ammonium Chloride (DADMAC) as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Diallyldimethyl Ammonium Chloride (DADMAC) allowed in the EU?
Diallyldimethyl Ammonium Chloride (DADMAC) EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diallyldimethyl Ammonium Chloride (DADMAC) do in cosmetics?
Diallyldimethyl Ammonium Chloride (DADMAC) functions as: Antistatic agent, hair conditioning (monomer for Polyquaternium-6). It is classified as a cosmetic ingredient in our database. CAS number: 7398-69-8.
What is the Margin of Safety for Diallyldimethyl Ammonium Chloride (DADMAC)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diallyldimethyl Ammonium Chloride (DADMAC)?
The NOAEL (No Observed Adverse Effect Level) for Diallyldimethyl Ammonium Chloride (DADMAC) is 200 mg/kg bw/day based on a oral study via oral route in dog. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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