Diammonium Dithiodiglycolate
INCI: DIAMMONIUM DITHIODIGLYCOLATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Diammonium Dithiodiglycolate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 60 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=180 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | >150 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=360 mg/kg bw/day | dermal | code:3543 | dermal | REACH |
| NOEL | 13 mg/kg bw/day | oral | - | oral | REACH |
| LOAEL | 21 mg/kg bw/day | dermal | - | dermal | REACH |
| NOEL | 43 mg/kg bw/day | dermal | - | dermal | REACH |
Expert Verdict
Thioglycolate salt subject to EU Annex III restrictions including maximum concentration limits, pH controls, and mandatory label warnings. High sensitization potential requires patch testing; alkaline conditions increase irritation risk. Professional-use formulations may permit higher concentrations than consumer products.
Regulatory Flags
Frequently Asked Questions
Is Diammonium Dithiodiglycolate safe in cosmetics?
Thioglycolate salt subject to EU Annex III restrictions including maximum concentration limits, pH controls, and mandatory label warnings. High sensitization potential requires patch testing; alkaline conditions increase irritation risk. Professional-use formulations may permit higher concentrations than consumer products. The EU classifies Diammonium Dithiodiglycolate as "restricted". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.
Is Diammonium Dithiodiglycolate allowed in the EU?
Diammonium Dithiodiglycolate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diammonium Dithiodiglycolate do in cosmetics?
Diammonium Dithiodiglycolate functions as: Hair waving or straightening (reducing agent / disulfide bond breaker). It is classified as a cosmetic ingredient in our database. CAS number: 68223-93-8.
What is the Margin of Safety for Diammonium Dithiodiglycolate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diammonium Dithiodiglycolate?
The NOAEL (No Observed Adverse Effect Level) for Diammonium Dithiodiglycolate is 60 mg/kg bw/day based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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