Poor Cosmetic Ingredient NOAEL Data GHS Classified

Dibutyl Ethanolamine

INCI: DIBUTYL ETHANOLAMINE

CAS Number
102-81-8
Function
Buffering agent
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted — not specifically prohibited under 21 CFR; FDA notes nitrosamine concerns with DEA-related amines generally

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Dibutyl Ethanolamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 50 mg/kg bw/day oral rat oral REACH
NOEL 25 mg/kg bw/day oral rat oral REACH
NOAEL 430 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is corrosive to the eyes and skin. The vapour is irritating to the respiratory tract. Corrosive on ingestion. The substance may cause effects on the central nervous system. This may result in convulsions and respiratory failure. Cholinesterase inhibition. Exposure could cause death. Medical observation is indicated. The effects may be delayed.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Expert Verdict

GHS H302 (harmful if swallowed), H312 (harmful dermal), H314 (severe burns/eye damage); Category 1A–1C skin corrosion; STOT SE Cat 2 (nervous system), Cat 3 (respiratory irritation); raises serious suitability questions for leave-on cosmetics; must not be used with nitrosating agents; requires rigorous in-use concentration justification in any CPSR

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Concern Level: High

Frequently Asked Questions

Is Dibutyl Ethanolamine safe in cosmetics?

GHS H302 (harmful if swallowed), H312 (harmful dermal), H314 (severe burns/eye damage); Category 1A–1C skin corrosion; STOT SE Cat 2 (nervous system), Cat 3 (respiratory irritation); raises serious suitability questions for leave-on cosmetics; must not be used with nitrosating agents; requires rigorous in-use concentration justification in any CPSR The EU classifies Dibutyl Ethanolamine as "prohibited". Safety rating: POOR. 3 toxicological study endpoint(s) are available in our database.

Is Dibutyl Ethanolamine allowed in the EU?

Dibutyl Ethanolamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Dibutyl Ethanolamine do in cosmetics?

Dibutyl Ethanolamine functions as: Buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 102-81-8.

What is the Margin of Safety for Dibutyl Ethanolamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dibutyl Ethanolamine?

The NOAEL (No Observed Adverse Effect Level) for Dibutyl Ethanolamine is 50 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

Compliance Tools

Check Dibutyl Ethanolamine compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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