Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Dibutyl Maleate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 30 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 95 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.30 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Not a recognized cosmetic ingredient per CIR review; low general toxicity but can cause skin and eye irritation on contact.
Frequently Asked Questions
Is Dibutyl Maleate safe in cosmetics?
Not a recognized cosmetic ingredient per CIR review; low general toxicity but can cause skin and eye irritation on contact. The EU classifies Dibutyl Maleate as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Dibutyl Maleate allowed in the EU?
Dibutyl Maleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibutyl Maleate do in cosmetics?
Dibutyl Maleate functions as: Plasticizer, comonomer intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 105-76-0.
What is the Margin of Safety for Dibutyl Maleate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dibutyl Maleate?
The NOAEL (No Observed Adverse Effect Level) for Dibutyl Maleate is 30 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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