Good Cosmetic Ingredient GHS Classified

Diethoxydiglycol

INCI: DIETHOXYDIGLYCOL

CAS Number
112-36-7
Function
Solvent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR: safe as used at reported concentrations (up to 4โ€“4.5% in leave-on)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is mildly irritating to the eyes and skin.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.

Expert Verdict

Structurally related to ethoxydiglycol (DEGEE), which SCCS flagged as a penetration enhancer. Monitor for potential EU reclassification. Impurity profile (1,4-dioxane) must be controlled. Use concentrations in leave-on: โ‰ค4.5% per CIR data.

โš ๏ธ
Concern Level: Low

Frequently Asked Questions

Is Diethoxydiglycol safe in cosmetics?

Structurally related to ethoxydiglycol (DEGEE), which SCCS flagged as a penetration enhancer. Monitor for potential EU reclassification. Impurity profile (1,4-dioxane) must be controlled. Use concentrations in leave-on: โ‰ค4.5% per CIR data. The EU classifies Diethoxydiglycol as "permitted". Safety rating: GOOD.

Is Diethoxydiglycol allowed in the EU?

Diethoxydiglycol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethoxydiglycol do in cosmetics?

Diethoxydiglycol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 112-36-7.

What is the Margin of Safety for Diethoxydiglycol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Diethoxydiglycol in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Diethoxydiglycol in your formulation.