Diethyl Malate

INCI: DIETHYL MALATE

CAS Number
7554-12-3 (DL-form)
Function
Skin conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CIR Expert Panel reviewed dialkyl malates and concluded them safe in present practices of use and concentration. Malic acid parent is endogenous (Krebs cycle). Monitor maleic acid impurity as a process contaminant.

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Concern Level: Low

Regulatory Flags

fda_food_additive jecfa_safe

Frequently Asked Questions

Is Diethyl Malate safe in cosmetics?

CIR Expert Panel reviewed dialkyl malates and concluded them safe in present practices of use and concentration. Malic acid parent is endogenous (Krebs cycle). Monitor maleic acid impurity as a process contaminant. The EU classifies Diethyl Malate as "permitted". Safety rating: GOOD.

Is Diethyl Malate allowed in the EU?

Diethyl Malate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethyl Malate do in cosmetics?

Diethyl Malate functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 7554-12-3 (DL-form).

What is the Margin of Safety for Diethyl Malate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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