Dihydroxybenzylidine Thiazolidinedione
INCI: DIHYDROXYBENZYLIDINE THIAZOLIDINEDIONE
Regulatory Status
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Safety Data
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Expert Verdict
Thiazolidinedione scaffold is the core of PPARγ agonist drugs (pioglitazone, rosiglitazone); a CPSR Safety Assessor will demand evidence that dermal exposure at proposed concentrations does not produce systemic PPARγ activation. No CIR review or SCCS opinion available; requires in-vitro PPARγ binding data or systemic exposure calculations.
Frequently Asked Questions
Is Dihydroxybenzylidine Thiazolidinedione safe in cosmetics?
Thiazolidinedione scaffold is the core of PPARγ agonist drugs (pioglitazone, rosiglitazone); a CPSR Safety Assessor will demand evidence that dermal exposure at proposed concentrations does not produce systemic PPARγ activation. No CIR review or SCCS opinion available; requires in-vitro PPARγ binding data or systemic exposure calculations. The EU classifies Dihydroxybenzylidine Thiazolidinedione as "prohibited". Safety rating: MODERATE.
Is Dihydroxybenzylidine Thiazolidinedione allowed in the EU?
Dihydroxybenzylidine Thiazolidinedione EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydroxybenzylidine Thiazolidinedione do in cosmetics?
Dihydroxybenzylidine Thiazolidinedione functions as: Skin Conditioning (thiazolidinedione-based cosmetic active). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly listed.
What is the Margin of Safety for Dihydroxybenzylidine Thiazolidinedione?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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