Dihydroxypropyl Didehydrolatanoprostamide

INCI: DIHYDROXYPROPYL DIDEHYDROLATANOPROSTAMIDE

CAS Number
1193782-16-9
Function
Eyelash/eyebrow growth promoter (prostaglandin F2α analogue derivative)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted by default — no specific CFR ban, but FDA enforcement precedent exists for the class

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

RED FLAG. Same profile as ingredient #4. The Danish EPA's 2025 survey specifically identified this CAS in commercial eyelash serums and noted it as a prostaglandin analogue of concern. This ingredient carries regulatory risk in the EU, and an imminent Annex II listing is plausible. CPSR inclusion requires a full toxicological justification under Article 10(1)(b) and will face RP and Competent Authority pushback.

⚠️
Concern Level: High

Frequently Asked Questions

Is Dihydroxypropyl Didehydrolatanoprostamide safe in cosmetics?

RED FLAG. Same profile as ingredient #4. The Danish EPA's 2025 survey specifically identified this CAS in commercial eyelash serums and noted it as a prostaglandin analogue of concern. This ingredient carries regulatory risk in the EU, and an imminent Annex II listing is plausible. CPSR inclusion requires a full toxicological justification under Article 10(1)(b) and will face RP and Competent Authority pushback. The EU classifies Dihydroxypropyl Didehydrolatanoprostamide as "permitted". Safety rating: POOR.

Is Dihydroxypropyl Didehydrolatanoprostamide allowed in the EU?

Dihydroxypropyl Didehydrolatanoprostamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dihydroxypropyl Didehydrolatanoprostamide do in cosmetics?

Dihydroxypropyl Didehydrolatanoprostamide functions as: Eyelash/eyebrow growth promoter (prostaglandin F2α analogue derivative). It is classified as a cosmetic ingredient in our database. CAS number: 1193782-16-9.

What is the Margin of Safety for Dihydroxypropyl Didehydrolatanoprostamide?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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