Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Diiodomethyltolylsulfone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 20 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 2 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| LOAEL | 10 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
Expert Verdict
Skin sensitizer (H317) and irritant (H315); causes irreversible eye damage; iodine-releasing agent with extremely low water solubility requiring particulate dispersion for formulation.
Regulatory Flags
Frequently Asked Questions
Is Diiodomethyltolylsulfone safe in cosmetics?
Skin sensitizer (H317) and irritant (H315); causes irreversible eye damage; iodine-releasing agent with extremely low water solubility requiring particulate dispersion for formulation. The EU classifies Diiodomethyltolylsulfone as "restricted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.
Is Diiodomethyltolylsulfone allowed in the EU?
Diiodomethyltolylsulfone EU regulatory status: restricted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Diiodomethyltolylsulfone do in cosmetics?
Diiodomethyltolylsulfone functions as: Preservative (fungicide); antimicrobial agent approved by CFTA/INCI for cosmetic preservation. It is classified as a cosmetic ingredient in our database. CAS number: 20018-09-1.
What is the Margin of Safety for Diiodomethyltolylsulfone?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diiodomethyltolylsulfone?
The NOAEL (No Observed Adverse Effect Level) for Diiodomethyltolylsulfone is 5 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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