Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dimethyl Maleate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 60 mg/kg bw/day | dermal | rat | dermal | REACH |
Expert Verdict
Dimethyl maleate is permitted in cosmetics but has poor safety profile with high sensitization potential and inadequate safety substantiation for cosmetic use.
Frequently Asked Questions
Is Dimethyl Maleate safe in cosmetics?
Dimethyl maleate is permitted in cosmetics but has poor safety profile with high sensitization potential and inadequate safety substantiation for cosmetic use. The EU classifies Dimethyl Maleate as "permitted". Safety rating: POOR. 1 toxicological study endpoint(s) are available in our database.
Is Dimethyl Maleate allowed in the EU?
Dimethyl Maleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Maleate do in cosmetics?
Dimethyl Maleate functions as: YELLOW. It is classified as a cosmetic ingredient in our database. CAS number: 624-48-6.
What is the Margin of Safety for Dimethyl Maleate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethyl Maleate?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Maleate is 60 mg/kg bw/day based on a dermal study via dermal route in rat. Source: REACH.
Compliance Tools
Check Dimethyl Maleate compliance across multiple jurisdictions:
Related Ingredients
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