Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Dimethyl Sulfone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 40 other | other | code:3544 | oral | REACH |
Expert Verdict
Dimethyl Sulfone has a favorable toxicological profile with non-genotoxic properties, low oral toxicity, and no sensitization concerns; formulators should stay at or below 1.0% in leave-on products to maintain a robust margin of safety.
Regulatory Flags
Frequently Asked Questions
Is Dimethyl Sulfone safe in cosmetics?
Dimethyl Sulfone has a favorable toxicological profile with non-genotoxic properties, low oral toxicity, and no sensitization concerns; formulators should stay at or below 1.0% in leave-on products to maintain a robust margin of safety. The EU classifies Dimethyl Sulfone as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Dimethyl Sulfone allowed in the EU?
Dimethyl Sulfone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Sulfone do in cosmetics?
Dimethyl Sulfone functions as: Solvent, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 67-71-0.
What is the Margin of Safety for Dimethyl Sulfone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethyl Sulfone?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Sulfone is 1500 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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