Good Cosmetic Ingredient NOAEL Data

Dimethylamino Methylpropanol (DMAMP)

Also known as: 1-Propanol, 2-(dimethylamino)-2-methyl-, BRN 1732837, 2-(Dimethylamino)-2-methylpropanol, 2-Dimethylamino-2-methyl-1-propanol, EINECS 230-279-6 (+2 more)

INCI: DIMETHYLAMINO METHYLPROPANOL

Dimethylamino Methylpropanol (DMAMP) (CAS 7005-47-2) is a cosmetic cosmetic ingredient functioning as Anticorrosive, pH adjuster/buffering agent. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 7005-47-2 →

Auto-generated CPSR Part A draft with source citations
Function
Anticorrosive, pH adjuster/buffering agent
Safety Rating
GOOD

Chemistry & Identifiers

Formula
C6H15NO
MW
117.19 g/mol
EC Number
230-279-6
PubChem CID
23435
IUPAC Name
2-(dimethylamino)-2-methylpropan-1-ol
InChIKey
XRIBIDPMFSLGFS-UHFFFAOYSA-N

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes Permitted — compliant with U.S. FD&C Act; also compliant with ASEAN and Brazil ANVISA

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethylamino Methylpropanol (DMAMP).

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Dimethylamino Methylpropanol (DMAMP). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =300 mg/kg bw/day oral Rat chronic ToxValDB_ECHA_IUCLID

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Dimethylamino Methylpropanol (DMAMP) across SCCS product categories, with measured dermal absorption where available.

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Corrosion inhibitor
Regulatory List Membership (1)
FDA Indirect Food Contact Additives

Expert Verdict

Expert safety assessment and concern-level summary for Dimethylamino Methylpropanol (DMAMP).

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Dimethylamino Methylpropanol (DMAMP) by CAS number or substance name.

Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Known Synonyms

1-Propanol, 2-(dimethylamino)-2-methyl- BRN 1732837 2-(Dimethylamino)-2-methylpropanol 2-Dimethylamino-2-methyl-1-propanol EINECS 230-279-6 NSC 17706 UNII-6ZWG40UQ9E

Chemical Function

Corrosion inhibitor

Regulatory Lists

CEDI Indirect additives food contact (10/2018)

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

ChEMBL ID
CHEMBL3182117
View full pharmaceutical profile →

Frequently Asked Questions

Is Dimethylamino Methylpropanol (DMAMP) safe in cosmetics?

Dimethylamino Methylpropanol (DMAMP) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is Dimethylamino Methylpropanol (DMAMP) allowed in the EU?

Dimethylamino Methylpropanol (DMAMP) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dimethylamino Methylpropanol (DMAMP) do in cosmetics?

Dimethylamino Methylpropanol (DMAMP) functions as: Anticorrosive, pH adjuster/buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 7005-47-2.

What is the NOAEL for Dimethylamino Methylpropanol (DMAMP)?

The NOAEL (No Observed Adverse Effect Level) for Dimethylamino Methylpropanol (DMAMP) is =300 mg/kg bw/day based on a chronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.

Is Dimethylamino Methylpropanol (DMAMP) used outside cosmetics?

Dimethylamino Methylpropanol (DMAMP) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Dimethylamino Methylpropanol (DMAMP) have different safety status in cosmetics vs industrial chemicals?

Dimethylamino Methylpropanol (DMAMP) is classified GHS Danger (H226, H302, H314, H315, H318) in the chemicals database but is allowed in EU cosmetics.

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Good Similar safety
Antioxidant
DIMETHYLAMINO METHYLPROPANOL
Good Chemical family
Anticorrosive
DIMER AMIDE
Good Browse nearby
Antimicrobial
DIMETHICONE/METHICONE COPOLYMER
Good Browse nearby
Anticaking

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