Poor Cosmetic Ingredient NOAEL Data GHS Classified

Dimethylaminoethyl Methacrylate (DMAEMA)

INCI: DIMETHYLAMINOETHYL METHACRYLATE

CAS Number
2867-47-2
Function
Monomer for synthesis of hair-fixing and film-forming polymers
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted as polymerisation feedstock; no specific CFR prohibition for cosmetic use; classified Acute Tox. 4 (oral + dermal)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Dimethylaminoethyl Methacrylate (DMAEMA). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 500 mg/kg bw/day oral rat oral REACH
NOAEL 200 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
corr
Hazard Statements
Combustible liquid Causes severe skin burns and eye damage Harmful to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes and skin. The substance is irritating to the respiratory tract. Corrosive on ingestion.

Expert Verdict

RED FLAG: Corrosive (Skin Corr. 1B), serious eye damage (Eye Dam. 1), strong skin sensitizer, toxic by ingestion/inhalation/skin; if listed on INCI should only appear as residual in polymer form with strict monomer limits; demand CoA showing residual DMAEMA <10 ppm

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Dimethylaminoethyl Methacrylate (DMAEMA) safe in cosmetics?

RED FLAG: Corrosive (Skin Corr. 1B), serious eye damage (Eye Dam. 1), strong skin sensitizer, toxic by ingestion/inhalation/skin; if listed on INCI should only appear as residual in polymer form with strict monomer limits; demand CoA showing residual DMAEMA <10 ppm The EU classifies Dimethylaminoethyl Methacrylate (DMAEMA) as "permitted". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.

Is Dimethylaminoethyl Methacrylate (DMAEMA) allowed in the EU?

Dimethylaminoethyl Methacrylate (DMAEMA) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dimethylaminoethyl Methacrylate (DMAEMA) do in cosmetics?

Dimethylaminoethyl Methacrylate (DMAEMA) functions as: Monomer for synthesis of hair-fixing and film-forming polymers. It is classified as a cosmetic ingredient in our database. CAS number: 2867-47-2.

What is the Margin of Safety for Dimethylaminoethyl Methacrylate (DMAEMA)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dimethylaminoethyl Methacrylate (DMAEMA)?

The NOAEL (No Observed Adverse Effect Level) for Dimethylaminoethyl Methacrylate (DMAEMA) is 500 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

Is Dimethylaminoethyl Methacrylate (DMAEMA) classified as hazardous under GHS?

Dimethylaminoethyl Methacrylate (DMAEMA) carries a GHS signal word of "DANGER". Hazard statements: Combustible liquid Causes severe skin burns and eye damage Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance โ€” at cosmetic use concentrations, hazard thresholds may not be met.

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