Is DIMETHYLBENZYL CARBINYL ACETATE safe in cosmetics?
DIMETHYLBENZYL CARBINYL ACETATE has a safety rating of "GOOD" in our database. EU status: permitted. 2 toxicological study endpoint(s) are available in our database.
DIMETHYLBENZYL CARBINYL ACETATE
Also known as: alpha,alpha-Dimethylphenethyl acetate, Benzeneethanol, .alpha.,.alpha.-dimethyl-, 1-acetate, Benzeneethanol, alpha,alpha-dimethyl-, 1-acetate, Benzyl dimethyl carbinyl acetate, Benzyldimethyl carbinyl acetate (+11 more)
DIMETHYLBENZYL CARBINYL ACETATE (CAS 151-05-3) is a cosmetic cosmetic ingredient functioning as Perfuming. Reported NOAEL =360 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 151-05-3 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
(2-methyl-1-phenylpropan-2-yl) acetate
InChIKey
FLUWAIIVLCVEKF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
2 study endpoints found for DIMETHYLBENZYL CARBINYL ACETATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =360 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
775 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [151] Kligman AM (1971): Report to RIFM, 2 April, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 107 | 0 | 1181 | 1181 | non-sensitizer |
| HMT | - | 0 | 2592 | - | - |
| HMT | - | 0 | 2592 | - | - |
| HMT | - | 0 | 2592 | - | - |
| HRIPT | - | 0 | 775 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (6)
JECFA Number
1655
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-BENZYL-2-PROPYL ACETATE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BENZYL DIMETHYL CARBINYL ACETATE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIMETHYL BENZYL CARBINYL ACETATE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-METHYL-1-PHENYL-2-PROPYL ACETATE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for DIMETHYLBENZYL CARBINYL ACETATE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to DIMETHYLBENZYL CARBINYL ACETATE by CAS number or substance name.
Studies
2
Lowest NOAEL
360 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
alpha,alpha-Dimethylphenethyl acetate
Benzeneethanol, .alpha.,.alpha.-dimethyl-, 1-acetate
Benzeneethanol, alpha,alpha-dimethyl-, 1-acetate
Benzyl dimethyl carbinyl acetate
Benzyldimethyl carbinyl acetate
Benzyldimethylcarbinol acetate
Benzyldimethylcarbinyl acetate
2-Benzyl-2-propyl acetate
BRN 1941670
alpha,alpha-Dimethylbenzeneethyl acetate
Dimethylbenzyl carbinol acetate
Dimethylbenzylcarbinol acetate
alpha,alpha-Dimethylphenethyl alcohol, acetate
EINECS 205-781-3
FEMA No. 2392
UNII-6Y9488RL8H
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
consumer_product
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3561182
Frequently Asked Questions
Is DIMETHYLBENZYL CARBINYL ACETATE allowed in the EU?
DIMETHYLBENZYL CARBINYL ACETATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does DIMETHYLBENZYL CARBINYL ACETATE do in cosmetics?
DIMETHYLBENZYL CARBINYL ACETATE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 151-05-3.
What is the NOAEL for DIMETHYLBENZYL CARBINYL ACETATE?
The NOAEL (No Observed Adverse Effect Level) for DIMETHYLBENZYL CARBINYL ACETATE is =360 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is DIMETHYLBENZYL CARBINYL ACETATE used outside cosmetics?
DIMETHYLBENZYL CARBINYL ACETATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check DIMETHYLBENZYL CARBINYL ACETATE compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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