Dioxolane (1,3-Dioxolane)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Dioxolane (1,3-Dioxolane). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 75 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 75 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Flammable liquid and eye irritant with limited cosmetic-specific toxicological data; residual solvent limits must be ensured in finished product and classified as hazardous substance under GHS.
Frequently Asked Questions
Is Dioxolane (1,3-Dioxolane) safe in cosmetics?
Flammable liquid and eye irritant with limited cosmetic-specific toxicological data; residual solvent limits must be ensured in finished product and classified as hazardous substance under GHS. The EU classifies Dioxolane (1,3-Dioxolane) as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Dioxolane (1,3-Dioxolane) allowed in the EU?
Dioxolane (1,3-Dioxolane) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dioxolane (1,3-Dioxolane) do in cosmetics?
Dioxolane (1,3-Dioxolane) functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 646-06-0.
What is the Margin of Safety for Dioxolane (1,3-Dioxolane)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dioxolane (1,3-Dioxolane)?
The NOAEL (No Observed Adverse Effect Level) for Dioxolane (1,3-Dioxolane) is 75 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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