Is Dipalmitoyl Glycerophosphocholine (DPPC) safe in cosmetics?
Dipalmitoyl Glycerophosphocholine (DPPC) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Dipalmitoyl Glycerophosphocholine (DPPC)
Also known as: Dipalmitoylphosphatidylcholine, EINECS 200-567-6, Colfoscerili palmitas, Palmitate de colfosceril, Palmitato de colfoscerilo (+15 more)
INCI: DIPALMITOYL GLYCEROPHOSPHOCHOLINE
Dipalmitoyl Glycerophosphocholine (DPPC) (CAS 63-89-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning, emollient (endogenous phospholipid — major component of. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 63-89-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, emollient (endogenous phospholipid — major component of pulmonary surfactant)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
[(2R)-2,3-di(hexadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
InChIKey
KILNVBDSWZSGLL-KXQOOQHDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no CFR restriction; phospholipids generally recognized as safe
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dipalmitoyl Glycerophosphocholine (DPPC).
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Dipalmitoyl Glycerophosphocholine (DPPC).
Known Synonyms
Dipalmitoylphosphatidylcholine
EINECS 200-567-6
Colfoscerili palmitas
Palmitate de colfosceril
Palmitato de colfoscerilo
UNII-319X2NFW0A
(2-{[(2R)-2,3-bis(hexadecanoyloxy)propyl phosphonato]oxy}ethyl)trimethylazanium
(R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide hydroxide inner salt
(R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide inner salt
1,2-Dihexadecanoyl-sn-glycerol-3-phosphorylcholine
1,2-Dipalmitoyl-L-a-lecithin
1,2-Dipalmitoyl-L-a-phosphatidylcholine
1,2-Dipalmitoyl-L-alpha-lecithin
1,2-Dipalmitoyl-L-alpha-phosphatidylcholine
1,2-Dipalmitoyl-rac-glycero-3-phosphocholine
1,2-Dipalmitoyl-sn-3-glycerophosphocholine
1,2-Dipalmitoyl-sn-glycerophosphorylcholine
1,2-L-a-Dipalmitoylphosphatidylcholine
1,2-L-alpha-Dipalmitoylphosphatidylcholine
1,2-dipalmitoylphosphatidylcholine
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
COLFOSCERIL PALMITATE
ChEMBL ID
CHEMBL1200737
Max Phase
4
Frequently Asked Questions
Is Dipalmitoyl Glycerophosphocholine (DPPC) allowed in the EU?
Dipalmitoyl Glycerophosphocholine (DPPC) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dipalmitoyl Glycerophosphocholine (DPPC) do in cosmetics?
Dipalmitoyl Glycerophosphocholine (DPPC) functions as: Skin conditioning, emollient (endogenous phospholipid — major component of pulmonary surfactant). It is classified as a cosmetic ingredient in our database. CAS number: 63-89-8.
Is Dipalmitoyl Glycerophosphocholine (DPPC) used outside cosmetics?
Dipalmitoyl Glycerophosphocholine (DPPC) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dipalmitoyl Glycerophosphocholine (DPPC) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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