Dipalmitoyl Glycerophosphocholine (DPPC)

INCI: DIPALMITOYL GLYCEROPHOSPHOCHOLINE

CAS Number
63-89-8
Function
Skin conditioning, emollient (endogenous phospholipid — major component of pulmonary surfactant)
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no CFR restriction; phospholipids generally recognized as safe

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

When used in liposomal delivery systems, may enhance dermal absorption of co-formulated ingredients — assess system-level safety; pharmaceutical-grade purity recommended; no inherent toxicological concern

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Concern Level: Low

Frequently Asked Questions

Is Dipalmitoyl Glycerophosphocholine (DPPC) safe in cosmetics?

When used in liposomal delivery systems, may enhance dermal absorption of co-formulated ingredients — assess system-level safety; pharmaceutical-grade purity recommended; no inherent toxicological concern The EU classifies Dipalmitoyl Glycerophosphocholine (DPPC) as "permitted". Safety rating: EXCELLENT.

Is Dipalmitoyl Glycerophosphocholine (DPPC) allowed in the EU?

Dipalmitoyl Glycerophosphocholine (DPPC) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dipalmitoyl Glycerophosphocholine (DPPC) do in cosmetics?

Dipalmitoyl Glycerophosphocholine (DPPC) functions as: Skin conditioning, emollient (endogenous phospholipid — major component of pulmonary surfactant). It is classified as a cosmetic ingredient in our database. CAS number: 63-89-8.

What is the Margin of Safety for Dipalmitoyl Glycerophosphocholine (DPPC)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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