Is Diphenolic Acid safe in cosmetics?
Diphenolic Acid has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Diphenolic Acid
Also known as: 4,4-Bis(4-hydroxyphenyl)valeric acid, Benzenebutanoic acid, 4-hydroxy-gamma-(4-hydroxyphenyl)-gamma-methyl-, Benzenebutanoic acid, 4-hydroxy-.gamma.-(4-hydroxyphenyl)-.gamma.-methyl-, 4,4-Bis(p-hydroxyphenyl)pentanoic acid, 4,4-Bis(4-hydroxyphenyl)pentanoic acid (+5 more)
INCI: DIPHENOLIC ACID
Diphenolic Acid (CAS 126-00-1) is a cosmetic cosmetic ingredient functioning as Chemical intermediate; structurally 4,4-bis(4-hydroxyphenyl)pentanoic acid (BPA. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 126-00-1 →
Auto-generated CPSR Part A draft with source citations
Function
Chemical intermediate; structurally 4,4-bis(4-hydroxyphenyl)pentanoic acid (BPA analog)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
4,4-bis(4-hydroxyphenyl)pentanoic acid
InChIKey
VKOUCJUTMGHNOR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not listed as a cosmetic ingredient in 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diphenolic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Viscosity modifier
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Diphenolic Acid.
Regulatory Flags
endocrine_disruptor
Known Synonyms
4,4-Bis(4-hydroxyphenyl)valeric acid
Benzenebutanoic acid, 4-hydroxy-gamma-(4-hydroxyphenyl)-gamma-methyl-
Benzenebutanoic acid, 4-hydroxy-.gamma.-(4-hydroxyphenyl)-.gamma.-methyl-
4,4-Bis(p-hydroxyphenyl)pentanoic acid
4,4-Bis(4-hydroxyphenyl)pentanoic acid
gamma,gamma-Bis(p-hydroxyphenyl)valeric acid
4,4-Bis(p-hydroxyphenyl)valeric acid
EINECS 204-763-2
NSC 3371
UNII-2SIZ2CO5L3
Chemical Function
Viscosity modifier
Regulatory Lists
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1325931
Frequently Asked Questions
Is Diphenolic Acid allowed in the EU?
Diphenolic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diphenolic Acid do in cosmetics?
Diphenolic Acid functions as: Chemical intermediate; structurally 4,4-bis(4-hydroxyphenyl)pentanoic acid (BPA analog). It is classified as a cosmetic ingredient in our database. CAS number: 126-00-1.
Is Diphenolic Acid used outside cosmetics?
Diphenolic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diphenolic Acid compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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