Diretinyl Ether

INCI: DIRETINYL ETHER

CAS Number
442662-30-8
Function
Skin conditioning agent (retinoid derivative — ether of two retinol molecules)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted — not restricted under 21 CFR Parts 700–740

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Retinoid with photosensitivity concerns and potential teratogenicity at systemic levels; limited published toxicological data warrants continued evaluation under evolving EU retinoid restrictions.

⚠️
Concern Level: High

Frequently Asked Questions

Is Diretinyl Ether safe in cosmetics?

Retinoid with photosensitivity concerns and potential teratogenicity at systemic levels; limited published toxicological data warrants continued evaluation under evolving EU retinoid restrictions. The EU classifies Diretinyl Ether as "prohibited". Safety rating: MODERATE.

Is Diretinyl Ether allowed in the EU?

Diretinyl Ether EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Diretinyl Ether do in cosmetics?

Diretinyl Ether functions as: Skin conditioning agent (retinoid derivative — ether of two retinol molecules). It is classified as a cosmetic ingredient in our database. CAS number: 442662-30-8.

What is the Margin of Safety for Diretinyl Ether?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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