Poor Cosmetic Ingredient Sensitization Data

Disperse Orange 3

INCI: DISPERSE ORANGE 3

CAS Number
| Disperse Black 9
Function
Hair dyeing (historically)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Annex Entry

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Disperse Orange 3 based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis

Source: IVDK; NACDG; ESSCA

Expert Verdict

Azo dye (4-[(4-Nitrophenyl)azo]aniline) that undergoes reductive cleavage to aromatic amines including p-phenylenediamine and p-nitroaniline; known sensitizer; prohibited in EU cosmetics but permitted in US.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Disperse Orange 3 safe in cosmetics?

Azo dye (4-[(4-Nitrophenyl)azo]aniline) that undergoes reductive cleavage to aromatic amines including p-phenylenediamine and p-nitroaniline; known sensitizer; prohibited in EU cosmetics but permitted in US. The EU classifies Disperse Orange 3 as "prohibited". Safety rating: POOR.

Is Disperse Orange 3 allowed in the EU?

Disperse Orange 3 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Disperse Orange 3 do in cosmetics?

Disperse Orange 3 functions as: Hair dyeing (historically). It is classified as a cosmetic ingredient in our database. CAS number: | Disperse Black 9.

What is the Margin of Safety for Disperse Orange 3?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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