Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Dodecane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | >=1800 2285 | 1995 | rat | inhalation | REACH |
| NOAEL | >=1800 2285 | inhalation | - | inhalation | REACH |
| NOAEL | >=5000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=5000 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | >=900 ppm | 1995 | rat | inhalation | REACH |
| NOAEL | >=900 ppm | inhalation | - | inhalation | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
Safe for cosmetic use with no EU annex restrictions, no concentration limits, and CIR endorsement; aspiration hazard is relevant only to raw material handling, not topical application.
Regulatory Flags
Frequently Asked Questions
Is Dodecane safe in cosmetics?
Safe for cosmetic use with no EU annex restrictions, no concentration limits, and CIR endorsement; aspiration hazard is relevant only to raw material handling, not topical application. The EU classifies Dodecane as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Dodecane allowed in the EU?
Dodecane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dodecane do in cosmetics?
Dodecane functions as: Fragrance, Emollient, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 112-40-3.
What is the Margin of Safety for Dodecane?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dodecane?
The NOAEL (No Observed Adverse Effect Level) for Dodecane is >=1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
Check Dodecane compliance across multiple jurisdictions:
Related Ingredients
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