Dodecyltriphenylphosphonium Bromide

INCI: DODECYLTRIPHENYLPHOSPHONIUM BROMIDE

CAS Number
15510-55-1
Function
Research agent for mitochondria targeting; inhibits oxidative phosphorylation; studied for anticancer and antibacterial applications
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Not listed for cosmetic use. No VCRP filings or 21 CFR cosmetic precedent exists.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CRITICAL FLAG: This is a pharmaceutical/research chemical, not a cosmetic ingredient. Selectively cytotoxic to cells at nanomolar to micromolar concentrations. Safety data sheets indicate eye irritant and potential skin irritant properties. Bromide counterion adds additional toxicological concern. Must not be incorporated into cosmetic formulations.

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Concern Level: High

Frequently Asked Questions

Is Dodecyltriphenylphosphonium Bromide safe in cosmetics?

CRITICAL FLAG: This is a pharmaceutical/research chemical, not a cosmetic ingredient. Selectively cytotoxic to cells at nanomolar to micromolar concentrations. Safety data sheets indicate eye irritant and potential skin irritant properties. Bromide counterion adds additional toxicological concern. Must not be incorporated into cosmetic formulations. The EU classifies Dodecyltriphenylphosphonium Bromide as "prohibited". Safety rating: POOR.

Is Dodecyltriphenylphosphonium Bromide allowed in the EU?

Dodecyltriphenylphosphonium Bromide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Dodecyltriphenylphosphonium Bromide do in cosmetics?

Dodecyltriphenylphosphonium Bromide functions as: Research agent for mitochondria targeting; inhibits oxidative phosphorylation; studied for anticancer and antibacterial applications. It is classified as a cosmetic ingredient in our database. CAS number: 15510-55-1.

What is the Margin of Safety for Dodecyltriphenylphosphonium Bromide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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