Ephedra Distachya Extract

INCI: EPHEDRA DISTACHYA EXTRACT

CAS Number
84625-36-5
Function
Skin conditioning / tonic
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Caution โ€” 21 CFR 119.1 bans ephedrine alkaloids in dietary supplements; cosmetics are not explicitly covered but ephedrine is a controlled substance (21 CFR 1308); FDA may view topical ephedra as misbranded/adulterated if drug claims are implied

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Ephedra distachya generally contains lower alkaloid levels than E. sinica but is not alkaloid-free; cardiovascular effects of ephedrine at systemic levels include hypertension, tachycardia, and stroke risk; alkaloid-free status must be demonstrated via HPLC for EU use and justified in CPSR by the Responsible Person.

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Concern Level: High

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Ephedra Distachya Extract safe in cosmetics?

Ephedra distachya generally contains lower alkaloid levels than E. sinica but is not alkaloid-free; cardiovascular effects of ephedrine at systemic levels include hypertension, tachycardia, and stroke risk; alkaloid-free status must be demonstrated via HPLC for EU use and justified in CPSR by the Responsible Person. The EU classifies Ephedra Distachya Extract as "prohibited". Safety rating: MODERATE.

Is Ephedra Distachya Extract allowed in the EU?

Ephedra Distachya Extract EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Ephedra Distachya Extract do in cosmetics?

Ephedra Distachya Extract functions as: Skin conditioning / tonic. It is classified as a cosmetic ingredient in our database. CAS number: 84625-36-5.

What is the Margin of Safety for Ephedra Distachya Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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