Moderate Cosmetic Ingredient NOAEL Data

Ethylal

INCI: ETHYLAL

CAS Number
462-95-3
Function
Solvent / Fragrance
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not specifically restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Ethylal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 750 ppm 1995 rat inhalation REACH
NOEL ca.2000 2285 1995 rat inhalation REACH
NOAEL ca.3930 2284 1995 rat inhalation REACH

Expert Verdict

GHS Hazard Statements: H225 (highly flammable liquid/vapour), H315 (skin irritation Cat 2), H319 (serious eye irritation Cat 2), H335 (respiratory irritation STOT SE 3). Flammability is a manufacturing/storage concern. Skin and eye irritation require concentration limits in leave-on products. Not classified for carcinogenicity, mutagenicity, or reproductive toxicity.

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Concern Level: Moderate

Regulatory Flags

fragrance-component

Frequently Asked Questions

Is Ethylal safe in cosmetics?

GHS Hazard Statements: H225 (highly flammable liquid/vapour), H315 (skin irritation Cat 2), H319 (serious eye irritation Cat 2), H335 (respiratory irritation STOT SE 3). Flammability is a manufacturing/storage concern. Skin and eye irritation require concentration limits in leave-on products. Not classified for carcinogenicity, mutagenicity, or reproductive toxicity. The EU classifies Ethylal as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.

Is Ethylal allowed in the EU?

Ethylal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethylal do in cosmetics?

Ethylal functions as: Solvent / Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 462-95-3.

What is the Margin of Safety for Ethylal?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethylal?

The NOAEL (No Observed Adverse Effect Level) for Ethylal is 750 ppm based on a inhalation study via 1995 route in rat. A total of 3 study endpoints are available. Source: REACH.

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