Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Phytoestrogen with estrogen receptor binding activity; potential endocrine-disrupting concern at high concentrations. Literature reports cancer cell proliferation stimulation at concentrations below 6 μM via ERK1/2 pathway with IC50 against cancer cells of 10–300 μM. Used in traditional medicine sources such as Astragalus and Red Clover. Typical cosmetic use levels are low, but margin of safety must be formally established.
Frequently Asked Questions
Is Formononetin safe in cosmetics?
Phytoestrogen with estrogen receptor binding activity; potential endocrine-disrupting concern at high concentrations. Literature reports cancer cell proliferation stimulation at concentrations below 6 μM via ERK1/2 pathway with IC50 against cancer cells of 10–300 μM. Used in traditional medicine sources such as Astragalus and Red Clover. Typical cosmetic use levels are low, but margin of safety must be formally established. The EU classifies Formononetin as "permitted". Safety rating: MODERATE.
Is Formononetin allowed in the EU?
Formononetin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Formononetin do in cosmetics?
Formononetin functions as: Skin conditioning (isoflavone; phytoestrogen). It is classified as a cosmetic ingredient in our database. CAS number: | Formaldehyde/Melamine/Tosylamide Copolymer.
What is the Margin of Safety for Formononetin?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Formononetin compliance across multiple jurisdictions:
Related Ingredients
Is Formononetin in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Formononetin in your formulation.