Excellent Cosmetic Ingredient NOAEL Data

Gellan Gum

INCI: GELLAN GUM

Gellan Gum (CAS 71010-52-1) is a cosmetic cosmetic ingredient functioning as gelling agent, rheology modifier, thickener, stabilizer. NOAEL 1460 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.

View industrial chemical safety profile for CAS 71010-52-1 →

Auto-generated CPSR Part A draft with source citations
Function
gelling agent, rheology modifier, thickener, stabilizer
Safety Rating
EXCELLENT

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes GRAS for food; FDA permitted. Widely used in cosmetics and pharmaceuticals.

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Gellan Gum.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Gellan Gum. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 2500 mg/kg bw/day oral rat Multigeneration Reproductive COSMOS_DB
NOAEL 3000 mg/kg bw/day oral monkey Short Term Toxicity COSMOS_DB
NOAEL 4900 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 6000 mg/kg bw/day oral rat Subchronic COSMOS_DB

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Gellan Gum across SCCS product categories, with measured dermal absorption where available.

EPA ToxValDB — Toxicity Values

3 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint Value Species Route Duration Source
LEL =200 mg/kg-day Human oral short-term EFSA
NOAEL =3627 mg/kg-day Mouse oral chronic EFSA
NOAEL =1460 mg/kg-day Rat oral chronic EFSA

Additional Ingredient Properties

10 property records from structured ingredient metadata.

acne
{"cas_number": "71010-52-1", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction…
anti_pollution
{"cas_number": "71010-52-1", "ingredient_class": "anti_pollution", "primary_mechanism": "film_forming_barrier", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB…
biopolymer
{"cas_number": "71010-52-1", "polymer_class": "microbial_gum", "botanical_source": "Sphingomonas elodea fermentation", "molecular_weight_range_kDa": "500-1000", "monosaccharide_composition": "glucose/glucuronic acid/rhamnose (2:1:1)", "degree_of_branching": "linear", "charge_type": "anionic", "viscosity_1pct_solution_mPas": "100-500", "pseudoplastic_behavior": "weak", "thixotropy": "no", "yield_st…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,combination,normal", "acne_safe": "yes", "source": "Ferment thickener"}
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "28-60", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "very low toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "palm_…
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "emulsifier_type": "o_w", "emulsion_stabilization_mechanism": "steric_stabilization", "co_emulsifier_pairs": "none_required", "optimal_oil_phase_pct": "3-15", "optimal_water_phase_pct": "85-97", "electrolyte_tolerance": "low", "pH_emulsion_stability_range": "3.0-10.0", "viscosity_building_contribution": "very_high", "droplet_size_range_um": "0.1-8", "zeta_poten…
hair_care
{"hair_function": "styling", "hair_type_suitability": "all", "curl_pattern_suitability": "curly/coily", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "k…
ph_stability
{"optimal_ph_min": "3.0", "optimal_ph_max": "10.0", "stable_ph_min": "3.0", "stable_ph_max": "11.0", "ph_dependent_function": "Good pH stability", "formulation_note": "Forms rigid or elastic gels", "source": "Formulation literature"}

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Film former Stabilizing agent Thickening agent Viscosity modifier
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)

Expert Verdict

Expert safety assessment and concern-level summary for Gellan Gum.

Regulatory Flags

eu-compliant biodegradable reach-spm-exempt natural-polymer cosmos-eligible gras cation-dependent-gelation fluid-gel microbial-origin novel-texture hydrogel fda_food_additive jecfa_safe

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Gellan Gum by CAS number or substance name.

Studies
4
Lowest NOAEL
2500 mg/kg bw/day
Highest NOAEL
6000 mg/kg bw/day
COSMOS_DB

Chemical Function

Film former Viscosity modifier Stabilizing agent Thickening agent

Regulatory Lists

inert_ingredient; non_food_use; Pesticides food_additive; Substances Added to Food (formerly EAFUS) (2/2019) inert_ingredient; Pesticides Canada; Personal care; Substances in PCP - Canada (4/2014)

Australian Status

AICIS status: listed

Frequently Asked Questions

Is Gellan Gum safe in cosmetics?

Gellan Gum has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.

Is Gellan Gum allowed in the EU?

Gellan Gum EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Gellan Gum do in cosmetics?

Gellan Gum functions as: gelling agent, rheology modifier, thickener, stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 71010-52-1.

What is the NOAEL for Gellan Gum?

The NOAEL (No Observed Adverse Effect Level) for Gellan Gum is 2500 mg/kg bw/day based on a Multigeneration Reproductive study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.

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