Gemfibroziloyl Pentapeptide-43

INCI: GEMFIBROZILOYL PENTAPEPTIDE-43

CAS Number
Not publicly assigned (novel peptide conjugate)
Function
Skin conditioning / anti-aging (lipopeptide class)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR; CIR has not individually reviewed; peptide class generally considered safe at reported use levels

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Novel peptide conjugate with sparse published toxicological data; residual free gemfibrozil must be quantified and shown below pharmacological threshold; CPSR assessor will require supplier safety dossier with HRIPT and genotoxicity testing.

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Concern Level: High

Frequently Asked Questions

Is Gemfibroziloyl Pentapeptide-43 safe in cosmetics?

Novel peptide conjugate with sparse published toxicological data; residual free gemfibrozil must be quantified and shown below pharmacological threshold; CPSR assessor will require supplier safety dossier with HRIPT and genotoxicity testing. The EU classifies Gemfibroziloyl Pentapeptide-43 as "permitted". Safety rating: MODERATE.

Is Gemfibroziloyl Pentapeptide-43 allowed in the EU?

Gemfibroziloyl Pentapeptide-43 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Gemfibroziloyl Pentapeptide-43 do in cosmetics?

Gemfibroziloyl Pentapeptide-43 functions as: Skin conditioning / anti-aging (lipopeptide class). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (novel peptide conjugate).

What is the Margin of Safety for Gemfibroziloyl Pentapeptide-43?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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