Glycidoxy Dimethicone

INCI: GLYCIDOXY DIMETHICONE

CAS Number
Not assigned (modified polydimethylsiloxane)
Function
Emollient, skin conditioning, crosslinking agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” dimethicone and derivatives are widely accepted; no specific CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

The glycidoxy (epoxide) functional group is a structural alert for skin sensitization and mutagenicity. In the polymerized/crosslinked form, free epoxide should be negligible. Residual epoxide content must be specified by supplier.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Glycidoxy Dimethicone safe in cosmetics?

The glycidoxy (epoxide) functional group is a structural alert for skin sensitization and mutagenicity. In the polymerized/crosslinked form, free epoxide should be negligible. Residual epoxide content must be specified by supplier. The EU classifies Glycidoxy Dimethicone as "permitted". Safety rating: MODERATE.

Is Glycidoxy Dimethicone allowed in the EU?

Glycidoxy Dimethicone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glycidoxy Dimethicone do in cosmetics?

Glycidoxy Dimethicone functions as: Emollient, skin conditioning, crosslinking agent. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (modified polydimethylsiloxane).

What is the Margin of Safety for Glycidoxy Dimethicone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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