Glycyl SH-Oligopeptide-4

INCI: GLYCYL SH-OLIGOPEPTIDE-4

CAS Number
Not assigned (glycine-conjugated derivative of SH-Oligopeptide-4; parent peptide CAS 77642-24-1)
Function
Skin conditioning — synthetic peptide related to Thymosin-β4 with anti-aging and regenerative claims
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no CFR restriction; not specifically CIR-reviewed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Novel biotech ingredient with very limited formal safety data. No CIR or SCCS assessment. Parent peptide (Thymosin-β4) has known biological activity — must ensure cosmetic-grade purity. Recommend commissioning HRIPT and in vitro genotoxicity.

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Concern Level: Moderate

Frequently Asked Questions

Is Glycyl SH-Oligopeptide-4 safe in cosmetics?

Novel biotech ingredient with very limited formal safety data. No CIR or SCCS assessment. Parent peptide (Thymosin-β4) has known biological activity — must ensure cosmetic-grade purity. Recommend commissioning HRIPT and in vitro genotoxicity. The EU classifies Glycyl SH-Oligopeptide-4 as "permitted". Safety rating: MODERATE.

Is Glycyl SH-Oligopeptide-4 allowed in the EU?

Glycyl SH-Oligopeptide-4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glycyl SH-Oligopeptide-4 do in cosmetics?

Glycyl SH-Oligopeptide-4 functions as: Skin conditioning — synthetic peptide related to Thymosin-β4 with anti-aging and regenerative claims. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (glycine-conjugated derivative of SH-Oligopeptide-4; parent peptide CAS 77642-24-1).

What is the Margin of Safety for Glycyl SH-Oligopeptide-4?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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