Glycyrrhiza Glabra Rhizome/Root Extract

INCI: GLYCYRRHIZA GLABRA RHIZOME/ROOT EXTRACT

CAS Number
84775-66-6
Function
Skin Conditioning, Soothing
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - no specific prohibition; CIR has assessed licorice-derived ingredients as safe in current cosmetic concentrations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Contains glycyrrhizic acid, which at high oral doses causes pseudoaldosteronism; topical sensitization is rare but possible; potential estrogenic activity at very high concentrations. Combines both rhizome and root fractions, providing a broader phytochemical profile including glycyrrhizin, glabridin, and flavonoids; strong anti-inflammatory and skin-lightening activity via tyrosinase inhibition

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Concern Level: Moderate

Regulatory Flags

plant-extract potential-allergen

Frequently Asked Questions

Is Glycyrrhiza Glabra Rhizome/Root Extract safe in cosmetics?

Contains glycyrrhizic acid, which at high oral doses causes pseudoaldosteronism; topical sensitization is rare but possible; potential estrogenic activity at very high concentrations. Combines both rhizome and root fractions, providing a broader phytochemical profile including glycyrrhizin, glabridin, and flavonoids; strong anti-inflammatory and skin-lightening activity via tyrosinase inhibition The EU classifies Glycyrrhiza Glabra Rhizome/Root Extract as "permitted". Safety rating: MODERATE.

Is Glycyrrhiza Glabra Rhizome/Root Extract allowed in the EU?

Glycyrrhiza Glabra Rhizome/Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glycyrrhiza Glabra Rhizome/Root Extract do in cosmetics?

Glycyrrhiza Glabra Rhizome/Root Extract functions as: Skin Conditioning, Soothing. It is classified as a cosmetic ingredient in our database. CAS number: 84775-66-6.

What is the Margin of Safety for Glycyrrhiza Glabra Rhizome/Root Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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