Glyoxylic Acid

INCI: GLYOXYLIC ACID

CAS Number
298-12-4
Function
Hair straightening / smoothing agent
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” FDA monitoring hair smoothing products for formaldehyde release under heat

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Glyoxylic acid releases formaldehyde when heated during application, with reports of acute kidney failure and renal tubular necrosis documented in France; EU-wide restriction likely pending.

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Concern Level: High

Frequently Asked Questions

Is Glyoxylic Acid safe in cosmetics?

Glyoxylic acid releases formaldehyde when heated during application, with reports of acute kidney failure and renal tubular necrosis documented in France; EU-wide restriction likely pending. The EU classifies Glyoxylic Acid as "permitted". Safety rating: POOR.

Is Glyoxylic Acid allowed in the EU?

Glyoxylic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glyoxylic Acid do in cosmetics?

Glyoxylic Acid functions as: Hair straightening / smoothing agent. It is classified as a cosmetic ingredient in our database. CAS number: 298-12-4.

What is the Margin of Safety for Glyoxylic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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