Gossypium Herbaceum Root Extract

INCI: GOSSYPIUM HERBACEUM ROOT EXTRACT

CAS Number
223749-08-4
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no CFR restriction; not CIR-reviewed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

High gossypol risk due to cotton root bark being a richest source of gossypol in the plant; traditional use as an abortifacient raises reproductive safety flags. Mandatory gossypol assay required and full toxicological dossier supporting specific use concentration essential. Heavy-metal accumulation from soil is possible.

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Concern Level: High

Regulatory Flags

plant-extract natural-origin

Frequently Asked Questions

Is Gossypium Herbaceum Root Extract safe in cosmetics?

High gossypol risk due to cotton root bark being a richest source of gossypol in the plant; traditional use as an abortifacient raises reproductive safety flags. Mandatory gossypol assay required and full toxicological dossier supporting specific use concentration essential. Heavy-metal accumulation from soil is possible. The EU classifies Gossypium Herbaceum Root Extract as "restricted". Safety rating: MODERATE.

Is Gossypium Herbaceum Root Extract allowed in the EU?

Gossypium Herbaceum Root Extract EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Gossypium Herbaceum Root Extract do in cosmetics?

Gossypium Herbaceum Root Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 223749-08-4.

What is the Margin of Safety for Gossypium Herbaceum Root Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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