Griffonia Simplicifolia Seed Extract
INCI: GRIFFONIA SIMPLICIFOLIA SEED EXTRACT
Regulatory Status
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Safety Data
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Expert Verdict
Contains 5-hydroxytryptophan (5-HTP), a serotonin precursor; topically considered safe at cosmetic concentrations; oral supplementation of 5-HTP carries systemic risks (serotonin syndrome potential), but this does not apply to standard cosmetic use. Demonstrated significant melanogenesis inhibitory activity (p < 0.01 at 0.004 mg/mL); patent filings describe use at 0.05-20% in depigmenting compositions; also promotes collagen synthesis indirectly through serotonin pathway influence
Regulatory Flags
Frequently Asked Questions
Is Griffonia Simplicifolia Seed Extract safe in cosmetics?
Contains 5-hydroxytryptophan (5-HTP), a serotonin precursor; topically considered safe at cosmetic concentrations; oral supplementation of 5-HTP carries systemic risks (serotonin syndrome potential), but this does not apply to standard cosmetic use. Demonstrated significant melanogenesis inhibitory activity (p < 0.01 at 0.004 mg/mL); patent filings describe use at 0.05-20% in depigmenting compositions; also promotes collagen synthesis indirectly through serotonin pathway influence The EU classifies Griffonia Simplicifolia Seed Extract as "permitted". Safety rating: MODERATE.
Is Griffonia Simplicifolia Seed Extract allowed in the EU?
Griffonia Simplicifolia Seed Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Griffonia Simplicifolia Seed Extract do in cosmetics?
Griffonia Simplicifolia Seed Extract functions as: Skin conditioning, skin lightening/depigmenting. It is classified as a cosmetic ingredient in our database. CAS number: 90045-52-6 (commonly cited for Griffonia simplicifolia extract).
What is the Margin of Safety for Griffonia Simplicifolia Seed Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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