Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Guanidine Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
No CIR review or SCCS opinion available. Anticipated to share the irritation profile of other guanidine salts including skin and eye irritation potential; read-across from guanidine carbonate may be accepted by toxicologists, but standalone data is preferred.
Frequently Asked Questions
Is Guanidine Phosphate safe in cosmetics?
No CIR review or SCCS opinion available. Anticipated to share the irritation profile of other guanidine salts including skin and eye irritation potential; read-across from guanidine carbonate may be accepted by toxicologists, but standalone data is preferred. The EU classifies Guanidine Phosphate as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Guanidine Phosphate allowed in the EU?
Guanidine Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guanidine Phosphate do in cosmetics?
Guanidine Phosphate functions as: Buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 5423-22-3.
What is the Margin of Safety for Guanidine Phosphate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Guanidine Phosphate?
The NOAEL (No Observed Adverse Effect Level) for Guanidine Phosphate is >=200 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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