Poor Cosmetic Ingredient NOAEL Data GHS Classified

Potassium Bromate

INCI: POTASSIUM BROMATE

CAS Number
7758-01-2
Function
Oxidizing agent historically used in permanent wave neutralizers
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Not explicitly banned in cosmetics but classified as a probable carcinogen; banned in food in many jurisdictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Potassium Bromate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 11.25 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 3.75 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 3.3 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 25 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 119.8 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 41.9 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 41.9 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 134.7 mg/kg bw/day oral hamster Carcinogenicity COSMOS_DB
NOAEL 300 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
NOAEL 300 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Ingestion could cause effects on the kidneys and central nervous system. This may result in renal failure, respiratory depression and hearing loss. The effects may be delayed.
Long-term Exposure Effects
This substance is possibly carcinogenic to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Expert Verdict

IARC Group 2B carcinogen with nephrotoxic and ototoxic effects; prohibited in EU cosmetics; do not use in any formulation

⚠️
Concern Level: High

Regulatory Flags

prop65 eu_banned_cosmetics fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Potassium Bromate safe in cosmetics?

IARC Group 2B carcinogen with nephrotoxic and ototoxic effects; prohibited in EU cosmetics; do not use in any formulation The EU classifies Potassium Bromate as "prohibited". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.

Is Potassium Bromate allowed in the EU?

Potassium Bromate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Potassium Bromate do in cosmetics?

Potassium Bromate functions as: Oxidizing agent historically used in permanent wave neutralizers. It is classified as a cosmetic ingredient in our database. CAS number: 7758-01-2.

What is the Margin of Safety for Potassium Bromate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Potassium Bromate?

The NOAEL (No Observed Adverse Effect Level) for Potassium Bromate is 11.25 mg/kg bw/day based on a Carcinogenicity study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Potassium Bromate compliance across multiple jurisdictions:

🔬
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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