Guanidinopentyl Phenylisoxazolecarboxamide

INCI: GUANIDINOPENTYL PHENYLISOXAZOLECARBOXAMIDE

CAS Number
Not readily available
Function
Skin conditioning (synthetic guanidine-isoxazole hybrid active)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted by default โ€” not restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Novel ingredient with pharmacological-class structural alerts (isoxazole-carboxamide scaffold appears in anticancer compound libraries). Full ADME, genotoxicity (Ames), in-vitro sensitization, and repeat-dose dermal toxicity studies required. No CIR or SCCS review exists. Treat as highest-priority data gap.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Guanidinopentyl Phenylisoxazolecarboxamide safe in cosmetics?

Novel ingredient with pharmacological-class structural alerts (isoxazole-carboxamide scaffold appears in anticancer compound libraries). Full ADME, genotoxicity (Ames), in-vitro sensitization, and repeat-dose dermal toxicity studies required. No CIR or SCCS review exists. Treat as highest-priority data gap. The EU classifies Guanidinopentyl Phenylisoxazolecarboxamide as "permitted". Safety rating: MODERATE.

Is Guanidinopentyl Phenylisoxazolecarboxamide allowed in the EU?

Guanidinopentyl Phenylisoxazolecarboxamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Guanidinopentyl Phenylisoxazolecarboxamide do in cosmetics?

Guanidinopentyl Phenylisoxazolecarboxamide functions as: Skin conditioning (synthetic guanidine-isoxazole hybrid active). It is classified as a cosmetic ingredient in our database. CAS number: Not readily available.

What is the Margin of Safety for Guanidinopentyl Phenylisoxazolecarboxamide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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