Harpagide

INCI: HARPAGIDE

CAS Number
6926-08-5
Function
Skin conditioning (iridoid glycoside from Harpagophytum procumbens — Devil's Claw)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no specific CFR prohibition; not an FDA-restricted cosmetic ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Predominantly used as a phytochemical reference standard with limited cosmetic-specific toxicological data; no CIR review or SCCS opinion available.

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Harpagide safe in cosmetics?

Predominantly used as a phytochemical reference standard with limited cosmetic-specific toxicological data; no CIR review or SCCS opinion available. The EU classifies Harpagide as "permitted". Safety rating: MODERATE.

Is Harpagide allowed in the EU?

Harpagide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Harpagide do in cosmetics?

Harpagide functions as: Skin conditioning (iridoid glycoside from Harpagophytum procumbens — Devil's Claw). It is classified as a cosmetic ingredient in our database. CAS number: 6926-08-5.

What is the Margin of Safety for Harpagide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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