Moderate Cosmetic Ingredient NOAEL Data

HC Yellow No. 13

INCI: HC YELLOW NO. 13

CAS Number
10442-83-8
Function
Semi-permanent (direct) hair dye — nitro dye class
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted — coal-tar hair dye exemption under FD&C Act §601(a)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for HC Yellow No. 13. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 10 mg/kg bw/day oral rat Subchronic COSMOS_DB
LOAEL 10 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Contains trifluoromethyl moiety; secondary amine structure presents nitrosamine risk with data gaps in toxicological evaluation noted by SCCNFP.

⚠️
Concern Level: High

Regulatory Flags

eu_cosing_listed

Frequently Asked Questions

Is HC Yellow No. 13 safe in cosmetics?

Contains trifluoromethyl moiety; secondary amine structure presents nitrosamine risk with data gaps in toxicological evaluation noted by SCCNFP. The EU classifies HC Yellow No. 13 as "prohibited". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is HC Yellow No. 13 allowed in the EU?

HC Yellow No. 13 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does HC Yellow No. 13 do in cosmetics?

HC Yellow No. 13 functions as: Semi-permanent (direct) hair dye — nitro dye class. It is classified as a cosmetic ingredient in our database. CAS number: 10442-83-8.

What is the Margin of Safety for HC Yellow No. 13?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for HC Yellow No. 13?

The NOAEL (No Observed Adverse Effect Level) for HC Yellow No. 13 is 10 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check HC Yellow No. 13 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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