Is HC Yellow No. 13 safe in cosmetics?
HC Yellow No. 13 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
HC Yellow No. 13
Also known as: UNII-0448DT2KKS, 4-(2-Hydroxyethylamino)-3-nitrobenzotrifluoride, Ethanol, 2-((2-nitro-4-(trifluoromethyl)phenyl)amino)-, Ethanol, 2-(alpha,alpha,alpha-trifluoro-2-nitro-p-toluidino)-, HC Yellow 13
INCI: HC YELLOW NO. 13
HC Yellow No. 13 (CAS 10442-83-8) is a cosmetic cosmetic ingredient functioning as Semi-permanent (direct) hair dye — nitro dye class. Reported NOAEL =30 mg/kg in rabbit (SCCNFP_vision_codex); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 10442-83-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HC Yellow No. 13 is prohibited in EU cosmetics but has active industrial GHS classifications (H411).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Semi-permanent (direct) hair dye — nitro dye class
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[2-nitro-4-(trifluoromethyl)anilino]ethanol
InChIKey
NJZCRXQWPNNJNB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — coal-tar hair dye exemption under FD&C Act §601(a)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Yellow No. 13.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Yellow No. 13. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =30 mg/kg | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =30 mg/kg | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =30 mg/kg | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =30 mg/kg | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =90 mg/kg bw | - | - | reproductive toxicity | SCCNFP_vision_codex |
| NOAEL | =90 mg/kg | oral | rat | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | =90 mg/kg bw | - | - | reproductive toxicity | SCCNFP_vision_codex |
| NOAEL | =90 mg/kg | oral | rat | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | =90 mg/kg bw | - | - | reproductive toxicity | SCCNFP_vision_codex |
| NOAEL | =90 mg/kg | oral | rat | developmental toxicity | SCCNFP_vision_codex |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,5% For (a) and (b): - Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/Kg - Keep in nitrite-free containers.
BRIN Brazil/India Cosmetics
India: Restricted
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "10442-83-8", "ingredient_class": "direct_dye", "chemical_class": "nitro", "molecular_weight_Da": "218.21", "color_result_on_hair": "Yellow", "shade_range": "blonde", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "moderate", "h…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Yellow No. 13.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Yellow No. 13 by CAS number or substance name.
Studies
12
Lowest NOAEL
30
Highest NOAEL
90
Units vary across source rows: mg/kg, mg/kg bw
SCCNFP_vision_codex
Known Synonyms
UNII-0448DT2KKS
4-(2-Hydroxyethylamino)-3-nitrobenzotrifluoride
Ethanol, 2-((2-nitro-4-(trifluoromethyl)phenyl)amino)-
Ethanol, 2-(alpha,alpha,alpha-trifluoro-2-nitro-p-toluidino)-
HC Yellow 13
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is HC Yellow No. 13 allowed in the EU?
HC Yellow No. 13 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Yellow No. 13 do in cosmetics?
HC Yellow No. 13 functions as: Semi-permanent (direct) hair dye — nitro dye class. It is classified as a cosmetic ingredient in our database. CAS number: 10442-83-8.
What is the NOAEL for HC Yellow No. 13?
The NOAEL (No Observed Adverse Effect Level) for HC Yellow No. 13 is =30 mg/kg based on a repeated dose toxicity study via dermal route in rabbit. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Is HC Yellow No. 13 used outside cosmetics?
HC Yellow No. 13 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HC Yellow No. 13 have different safety status in cosmetics vs industrial chemicals?
HC Yellow No. 13 is prohibited in EU cosmetics but has active industrial GHS classifications (H411).
Compliance Tools
Check HC Yellow No. 13 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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