Hesperetin

INCI: HESPERETIN

CAS Number
520-33-2
Function
Antioxidant, skin conditioning, skin protecting, anti-inflammatory
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific prohibition or restriction under 21 CFR; general safety clause applies

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Pure-grade powder exhibits GHS Category 2 skin/eye irritant and Category 4 acute oral toxicity; however, at finished-product cosmetic concentrations, the risk profile is favorable with no specific SCCS cosmetic use opinion required.

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Concern Level: Low

Regulatory Flags

endocrine_disruptor fda_food_additive

Frequently Asked Questions

Is Hesperetin safe in cosmetics?

Pure-grade powder exhibits GHS Category 2 skin/eye irritant and Category 4 acute oral toxicity; however, at finished-product cosmetic concentrations, the risk profile is favorable with no specific SCCS cosmetic use opinion required. The EU classifies Hesperetin as "permitted". Safety rating: GOOD.

Is Hesperetin allowed in the EU?

Hesperetin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hesperetin do in cosmetics?

Hesperetin functions as: Antioxidant, skin conditioning, skin protecting, anti-inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: 520-33-2.

What is the Margin of Safety for Hesperetin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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