Is Hexadecanolactone safe in cosmetics?
Hexadecanolactone has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Hexadecanolactone
Also known as: 16-Hexadecanolide, 5-17-09-00108, BRN 0148631, Cyclohexadecanolide, Dihydroambrettolide (+11 more)
INCI: HEXADECANOLACTONE
Hexadecanolactone (CAS 109-29-5) is a cosmetic cosmetic ingredient functioning as Fragrance (musky note). NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 109-29-5 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (musky note)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
oxacycloheptadecan-2-one
InChIKey
LOKPJYNMYCVCRM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction; IFRA maximum use levels apply
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexadecanolactone.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Hexadecanolactone across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
465 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [10] Kligman AM (1974): Report to RIFM, 12 September, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
| HRIPT | - | 0 | 465 | - | - |
| HRIPT | - | 0 | - | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Hexadecanolactone.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
Known Synonyms
16-Hexadecanolide
5-17-09-00108
BRN 0148631
Cyclohexadecanolide
Dihydroambrettolide
EINECS 203-662-0
1,16-Hexadecalactone
Hexadecanoic acid, 16-hydroxy-, omicron-lactone
1,16-Hexadecanolactone
16-Hexadecanolactone
Hexadecanolide
1,16-Hexadecanolide
16-Hydroxyhexadecanoic acid lactone
Juniperic acid lactone
NSC 33546
UNII-64E2HO00C7
Chemical Function
Deodorizer
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
consumer_product
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3189021
Frequently Asked Questions
Is Hexadecanolactone allowed in the EU?
Hexadecanolactone EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexadecanolactone do in cosmetics?
Hexadecanolactone functions as: Fragrance (musky note). It is classified as a cosmetic ingredient in our database. CAS number: 109-29-5.
Is Hexadecanolactone used outside cosmetics?
Hexadecanolactone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hexadecanolactone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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