Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Hexadecanolactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Weak skin sensitizer subject to IFRA category-specific concentration limits (0.42% in lip products, 2.5% in face/body leave-on products). Not genotoxic or phototoxic.
Regulatory Flags
Frequently Asked Questions
Is Hexadecanolactone safe in cosmetics?
Weak skin sensitizer subject to IFRA category-specific concentration limits (0.42% in lip products, 2.5% in face/body leave-on products). Not genotoxic or phototoxic. The EU classifies Hexadecanolactone as "restricted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is Hexadecanolactone allowed in the EU?
Hexadecanolactone EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexadecanolactone do in cosmetics?
Hexadecanolactone functions as: Fragrance (musky note). It is classified as a cosmetic ingredient in our database. CAS number: 109-29-5.
What is the Margin of Safety for Hexadecanolactone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hexadecanolactone?
The NOAEL (No Observed Adverse Effect Level) for Hexadecanolactone is 1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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