Is Hexamethylene Bis-hydroxystearamide safe in cosmetics?
Hexamethylene Bis-hydroxystearamide has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hexamethylene Bis-hydroxystearamide
INCI: HEXAMETHYLENE BIS-HYDROXYSTEARAMIDE
Hexamethylene Bis-hydroxystearamide (CAS 55349-01-4) is a cosmetic cosmetic ingredient functioning as Hair conditioning, humectant, skin conditioning. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 55349-01-4 →
Auto-generated CPSR Part A draft with source citations
Function
Hair conditioning, humectant, skin conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
12-hydroxy-N-[6-(12-hydroxyoctadecanoylamino)hexyl]octadecanamide
InChIKey
CXPIOTOKMJNFSA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexamethylene Bis-hydroxystearamide.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Hexamethylene Bis-hydroxystearamide across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Hexamethylene Bis-hydroxystearamide.
Regulatory Flags
potential-allergen
Chemical Function
Humectant
Softener and conditioner
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hexamethylene Bis-hydroxystearamide allowed in the EU?
Hexamethylene Bis-hydroxystearamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexamethylene Bis-hydroxystearamide do in cosmetics?
Hexamethylene Bis-hydroxystearamide functions as: Hair conditioning, humectant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 55349-01-4.
Compliance Tools
Check Hexamethylene Bis-hydroxystearamide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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