Regulatory Status
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Safety Data
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Expert Verdict
Cytotoxicity observed at ≥10 µM in vitro (IC50 = 34.9 µM HEK-293 cells); neurotransmitter inhibition at IC50 = 110 µM (5000× weaker than BoNT-A). Use concentration in cosmetics is orders of magnitude below concern thresholds. MW = 889 Da.
Frequently Asked Questions
Is Hexapeptide-8 safe in cosmetics?
Cytotoxicity observed at ≥10 µM in vitro (IC50 = 34.9 µM HEK-293 cells); neurotransmitter inhibition at IC50 = 110 µM (5000× weaker than BoNT-A). Use concentration in cosmetics is orders of magnitude below concern thresholds. MW = 889 Da. The EU classifies Hexapeptide-8 as "permitted". Safety rating: GOOD.
Is Hexapeptide-8 allowed in the EU?
Hexapeptide-8 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-8 do in cosmetics?
Hexapeptide-8 functions as: Skin conditioning agent, humectant, neurotransmitter release inhibitor (SNAP-25 analog), anti-wrinkle. It is classified as a cosmetic ingredient in our database. CAS number: 616204-22-9 (Acetyl Hexapeptide-8 Amide).
What is the Margin of Safety for Hexapeptide-8?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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