Good Active Ingredient SCCS/CIR Reviewed

Argireline (Acetyl Hexapeptide-3)

INCI: ACETYL HEXAPEPTIDE-3

CAS Number
616204-22-9
Function
Anti-aging peptide
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: safe

d palmitoyl tetrapeptide-7 as used in cosmetics.2 The Panel concluded that these ingredients are safe in cosmetics in the present practices of use and concentration, as described in that safety assessment. (This report is available on the Cosmetic Ingredient Review (CIR) website: https://cir-reports.

Expert Verdict

Good safety profile with negligible systemic absorption due to large molecular size; generally considered safe for cosmetic use.

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Concern Level: Low

Frequently Asked Questions

Is Argireline (Acetyl Hexapeptide-3) safe in cosmetics?

Good safety profile with negligible systemic absorption due to large molecular size; generally considered safe for cosmetic use. The EU classifies Argireline (Acetyl Hexapeptide-3) as "permitted". Safety rating: GOOD. This ingredient has been reviewed by cir.

Is Argireline (Acetyl Hexapeptide-3) allowed in the EU?

Argireline (Acetyl Hexapeptide-3) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Argireline (Acetyl Hexapeptide-3) do in cosmetics?

Argireline (Acetyl Hexapeptide-3) functions as: Anti-aging peptide. It is classified as a Active Ingredient in our database. CAS number: 616204-22-9.

What is the Margin of Safety for Argireline (Acetyl Hexapeptide-3)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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