Is Hexyl Methyl Ketone safe in cosmetics?
Hexyl Methyl Ketone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hexyl Methyl Ketone
Also known as: 2-Oxooctane, Methyl hexyl ketone, 4-01-00-03339, BRN 0635843, EINECS 203-837-1 (+4 more)
INCI: HEXYL METHYL KETONE
Hexyl Methyl Ketone (CAS 111-13-7) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 111-13-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
octan-2-one
InChIKey
ZPVFWPFBNIEHGJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS; no 21 CFR 700 restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexyl Methyl Ketone.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
2-Octanone has a relatively low toxicity. Direct skin contact may cause defatting and irritation of the skin. Inhalation may produce mild symptoms of eye, nose, and throat irritation at low concentrations, and may cause /CNS depression/ at high concentrations.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (3)
JECFA Number
288
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-OCTANONE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/59 | FAS 42-JECFA 51/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEXYL METHYL KETONE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/59 | FAS 42-JECFA 51/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Hexyl Methyl Ketone.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
2-Oxooctane
Methyl hexyl ketone
4-01-00-03339
BRN 0635843
EINECS 203-837-1
FEMA No. 2802
FEMA Number 2802
UNII-J2G84H29AF
FEMA 2802
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Europe; Toys and children's products
artificial_sweat; detected; emissions; Europe; Toys and children's products
artificial_sweat; detected; emissions; Europe; Toys and children's products
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL18549
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
2-OCTANONE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Hexyl Methyl Ketone allowed in the EU?
Hexyl Methyl Ketone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexyl Methyl Ketone do in cosmetics?
Hexyl Methyl Ketone functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 111-13-7.
Is Hexyl Methyl Ketone used outside cosmetics?
Hexyl Methyl Ketone also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hexyl Methyl Ketone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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