Moderate Cosmetic Ingredient NOAEL Data

Hexyldecanoic Acid

INCI: HEXYLDECANOIC ACID

CAS Number
25354-97-6
Function
Cleansing, surfactant (cleansing), surfactant (emulsifying)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - no specific prohibition or restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Hexyldecanoic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral - oral REACH
NOAEL >=1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

GHS classified as Skin Irritant Category 2 (H315), Skin Sensitizer 1B (H317), Aquatic Acute 1 (H400), and Aquatic Chronic 2 (H411). Synthetic-origin branched-chain fatty acid; acts as both a surfactant and emulsifier, meaning it can stabilize oil-water emulsions while providing cleansing performance; the hexyl-branching confers different skin-feel and solubility properties compared to straight-chain C16 acids

โš ๏ธ
Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Hexyldecanoic Acid safe in cosmetics?

GHS classified as Skin Irritant Category 2 (H315), Skin Sensitizer 1B (H317), Aquatic Acute 1 (H400), and Aquatic Chronic 2 (H411). Synthetic-origin branched-chain fatty acid; acts as both a surfactant and emulsifier, meaning it can stabilize oil-water emulsions while providing cleansing performance; the hexyl-branching confers different skin-feel and solubility properties compared to straight-chain C16 acids The EU classifies Hexyldecanoic Acid as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.

Is Hexyldecanoic Acid allowed in the EU?

Hexyldecanoic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexyldecanoic Acid do in cosmetics?

Hexyldecanoic Acid functions as: Cleansing, surfactant (cleansing), surfactant (emulsifying). It is classified as a cosmetic ingredient in our database. CAS number: 25354-97-6.

What is the Margin of Safety for Hexyldecanoic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Hexyldecanoic Acid?

The NOAEL (No Observed Adverse Effect Level) for Hexyldecanoic Acid is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

๐Ÿ“ฑ

Is Hexyldecanoic Acid in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hexyldecanoic Acid in your formulation.