Moderate Cosmetic Ingredient NOAEL Data

Hexyldecanoic Acid (2-Hexyldecanoic Acid)

INCI: HEXYLDECANOIC ACID

CAS Number
25354-97-6
Function
Surfactant / skin-conditioning agent (emollient)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not in 21 CFR 700/250 prohibited/restricted lists

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Hexyldecanoic Acid (2-Hexyldecanoic Acid). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral - oral REACH
NOAEL >=1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

GHS: Skin Irrit. 2 (H315), Skin Sens. 1B (H317), Aquatic Acute 1 (H400), Aquatic Chronic 2 (H411); eye irritation reported (H319); requires HRIPT at intended use concentration; environmental aquatic toxicity concern

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Concern Level: High

Frequently Asked Questions

Is Hexyldecanoic Acid (2-Hexyldecanoic Acid) safe in cosmetics?

GHS: Skin Irrit. 2 (H315), Skin Sens. 1B (H317), Aquatic Acute 1 (H400), Aquatic Chronic 2 (H411); eye irritation reported (H319); requires HRIPT at intended use concentration; environmental aquatic toxicity concern The EU classifies Hexyldecanoic Acid (2-Hexyldecanoic Acid) as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.

Is Hexyldecanoic Acid (2-Hexyldecanoic Acid) allowed in the EU?

Hexyldecanoic Acid (2-Hexyldecanoic Acid) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexyldecanoic Acid (2-Hexyldecanoic Acid) do in cosmetics?

Hexyldecanoic Acid (2-Hexyldecanoic Acid) functions as: Surfactant / skin-conditioning agent (emollient). It is classified as a cosmetic ingredient in our database. CAS number: 25354-97-6.

What is the Margin of Safety for Hexyldecanoic Acid (2-Hexyldecanoic Acid)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Hexyldecanoic Acid (2-Hexyldecanoic Acid)?

The NOAEL (No Observed Adverse Effect Level) for Hexyldecanoic Acid (2-Hexyldecanoic Acid) is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

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