Moderate Cosmetic Ingredient

Human Anti-Propionibacterium Acnes Monoclonal Antibody

INCI: HUMAN ANTI-PROPIONIBACTERIUM ACNES MONOCLONAL ANTIBODY

CAS Number
Not assigned
Function
Skin conditioning (anti-blemish/antimicrobial targeting)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status restricted
US Notes Highly restricted - monoclonal antibodies are typically regulated as biologics; cosmetic use would require no therapeutic claims, but functional antibody activity strongly suggests drug/biologic classification

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Immunogenicity risk; potential disruption of skin microbiome equilibrium; unclear long-term safety profile for topical mAb application; antibody stability in formulations. Engineered via phage display from human PBMCs immunized with P. acnes; exhibits specific binding to Cutibacterium acnes (formerly P. acnes); produced in CHO cells

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Concern Level: Moderate

Frequently Asked Questions

Is Human Anti-Propionibacterium Acnes Monoclonal Antibody safe in cosmetics?

Immunogenicity risk; potential disruption of skin microbiome equilibrium; unclear long-term safety profile for topical mAb application; antibody stability in formulations. Engineered via phage display from human PBMCs immunized with P. acnes; exhibits specific binding to Cutibacterium acnes (formerly P. acnes); produced in CHO cells The EU classifies Human Anti-Propionibacterium Acnes Monoclonal Antibody as "prohibited". Safety rating: MODERATE.

Is Human Anti-Propionibacterium Acnes Monoclonal Antibody allowed in the EU?

Human Anti-Propionibacterium Acnes Monoclonal Antibody EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Human Anti-Propionibacterium Acnes Monoclonal Antibody do in cosmetics?

Human Anti-Propionibacterium Acnes Monoclonal Antibody functions as: Skin conditioning (anti-blemish/antimicrobial targeting). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for Human Anti-Propionibacterium Acnes Monoclonal Antibody?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Human Anti-Propionibacterium Acnes Monoclonal Antibody compliance across multiple jurisdictions:

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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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