Moderate Cosmetic Ingredient

Human Placental Enzymes

CAS Number
91080-01-2 (related; hydrolyzed human placental protein)
Function
Softener and conditioner
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted; historically used in US cosmetic products (hair/skin treatments)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Bloodborne pathogen risk from placental tissue; enzymatic activity may cause irritation and sensitization at improper pH; batch variability and ethical sourcing concerns limit safety assurance despite historical anecdotal use data.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Human Placental Enzymes safe in cosmetics?

Bloodborne pathogen risk from placental tissue; enzymatic activity may cause irritation and sensitization at improper pH; batch variability and ethical sourcing concerns limit safety assurance despite historical anecdotal use data. The EU classifies Human Placental Enzymes as "prohibited". Safety rating: MODERATE.

Is Human Placental Enzymes allowed in the EU?

Human Placental Enzymes EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Human Placental Enzymes do in cosmetics?

Human Placental Enzymes functions as: Softener and conditioner. It is classified as a cosmetic ingredient in our database. CAS number: 91080-01-2 (related; hydrolyzed human placental protein).

What is the Margin of Safety for Human Placental Enzymes?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Human Placental Enzymes compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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