Humulus lupulus Extract

INCI: HUMULUS LUPULUS EXTRACT

CAS Number
8060-28-4 / 8016-25-9
Function
Antimicrobial, skin conditioning, tonic
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” GRAS under 21 CFR 182.20 (essential oils, oleoresins, natural extractives). CIR concluded safe as used when formulated to be non-sensitizing (2017)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Weak estrogenic activity from 8-prenylnaringenin; ฮฒ-myrcene may be present but rodent carcinogenicity data at high oral doses are not relevant at cosmetic-use concentrations; must be formulated to be non-sensitizing and compositional analysis recommended for each batch.

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Concern Level: Moderate

Regulatory Flags

plant-extract potential-allergen

Frequently Asked Questions

Is Humulus lupulus Extract safe in cosmetics?

Weak estrogenic activity from 8-prenylnaringenin; ฮฒ-myrcene may be present but rodent carcinogenicity data at high oral doses are not relevant at cosmetic-use concentrations; must be formulated to be non-sensitizing and compositional analysis recommended for each batch. The EU classifies Humulus lupulus Extract as "permitted". Safety rating: GOOD.

Is Humulus lupulus Extract allowed in the EU?

Humulus lupulus Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Humulus lupulus Extract do in cosmetics?

Humulus lupulus Extract functions as: Antimicrobial, skin conditioning, tonic. It is classified as a cosmetic ingredient in our database. CAS number: 8060-28-4 / 8016-25-9.

What is the Margin of Safety for Humulus lupulus Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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